منابع مشابه
Insulin says NO to cardiovascular disease.
It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin has been used as an essential therapeutic agent in diabetes for blood glucose management. Recent studies demonstrate that insulin signalling is essential for normal cardiovascular function, and lack of it (i...
متن کاملDDAH says NO to ADMA.
Endothelium-derived nitric oxide (NO) is vasoprotective, as it enhances endothelial cell survival and proliferation, inhibits the excessive proliferation of vascular smooth muscle cells, and suppresses the adhesion of platelets and inflammatory cells to the vessel wall.1 Substantial evidence from preclinical studies and human research indicates that impairment of the endothelial NO synthase (NO...
متن کاملPDE5 says NO to cGMP
A protease inhibitor unsticks cells AI-1 is unique among protease inhibitors because it binds to the matrix protein vitronectin (VN). PAI-1 binding blocks VN's binding site for the cell surface receptor uPAR and for integrin family members. Czekay et al. (page 781) now show that PAI-1 is also able to detach cells through a less direct approach. Unlike the direct competition method, PAI-1 also d...
متن کاملFolic acid says NO to vascular diseases.
OBJECTIVES The possible link between folic acid or folate and tetrahydrobiopterin (H(4)B), vitamin C, polyunsaturated fatty acids (PUFAs), and nitric oxide (NO), which may explain the beneficial actions of these nutrients in various vascular conditions, was investigated. METHODS The literature pertaining to the actions of folic acid/folate, H(4)B, vitamin C, PUFAs, and NO was reviewed. RESU...
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itations encountered in gene therapy, such as low gene expression, difficulties in producing adequate vector amounts, immune responses caused by non-specific transduction, and non-specific gene integration could be overcome by improving vector targeting. The bulk of the book (Parts 1 and 2) is dedicated to articles about transductional targeting strategies, meaning ways to design or manipulate ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2010
ISSN: 0008-6363
DOI: 10.1093/cvr/cvq349